MRTX-EX185 (formic) is a small-molecule inhibitor of KRAS with potent activity against the oncogenic G12D mutant (IC50 = 90 nM). It binds both GDP-loaded and GNP (GTP-mimetic) states of KRAS and is intended for biochemical, cellular, and tumor-model research. The compound is supplied as a purified solid (yellow to brown), with reported purity around 97.2%, molecular formula C34H35FN6O4, and molecular weight 610.68 g·mol⁻¹.
- Potent KRAS G12D inhibition (IC50 = 90 nM).
- Binds both GDP-loaded and GTP-mimetic states of KRAS.
- Applicable to in vitro and in vivo research studies.
- High reported purity, suitable for research use.
- Readily soluble in DMSO (125 mg/mL) for assay preparation.
- Stable as powder when stored at -20°C for long-term storage.